Started From The Bottom Now We’re Here: Pregnenolone (Hormone Lesson #2)

(Click here for lesson #1)

Let’s talk pregnenolone.


Don’t worry, it’s not about getting pregnant. Though it helps you to get there. If that’s what you want.

So, pregnenolone is a hormone (see! We ARE talking hormones here – we’ll get to the ones you’ve heard of soon enough) that actually helps to produce a whole lot of other hormones, like estrogen, progesterone, testosterone, DHEA, and cortisol (oh look, we got to ones you’ve heard of much more quickly than expected).

What is the NUMBER ONE coolest thing about pregnenolone? It’s produced from CHOLESTEROL, that thing that everyone talks about like it’s the devil incarnate. Turns out cholesterol is pretty damn important for your overall health and well-being, nanabooboo.

Okay, childhood tantrum aside, let’s begin with some of the ways that pregnenolone works for YOU, baby. It:

So yeah, it’s pretty cool. And it’s also damn important to understand how it’s related to those other hormones you are probably more interested in, namely estrogen, progesterone, and testosterone.

Word To Your Mutha

Pregnenolone is often referred to as the “mother” hormone (though one website I came across referred to it as the “grandparent” of steroid hormones – can you guess the sex of that author?). As I mentioned above, it’s made from cholesterol, mostly in the mitochondria of the adrenal gland, though some is made in the ovaries in women and testes in men, and also, interestingly enough, the brain (hence its memory-protecting activity).

**It’s very important to remember that pregenolone is (mostly) made in the adrenal glands. Do you know what else is? Cortisol, which you’ve probably heard a bit about. But we’ll come back to that later.**

So when that pregnenolone is thinking about converting to sex hormones, who’s deciding it’s time? You guessed it – the PITUITARY GLAND!! Remember, you learned last week that the pituitary releases Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH)?  Well, LH binds to target cells that promote the transfer of cholesterol to the inner mitochondria, and there is where the all the pregnenolone magic happens.

See? It’s all coming together, right? Right?

Okay, if it’s not, lemme draw a little picture (or really, let someone else do it, in this case, Lionel Robertson:

So as you can see, LH nudges cholesterol to do its thing and create pregnenolone.

Finally, we can get to the nitty-gritty of why pregnenolone is so damn important:


🔥Progesterone🔥 and 🔥DHEA🔥


Yes, pregnenolone is the precursor for these very-important-to-you-and-to-me hormones, and all the ones that flow out from it. From here, progesterone can be used to make aldosterone and cortisol. DHEA starts cranking out androstenedione, which makes the estrogens (estradiol, estriol, and estrone) and testosterone.
Remember earlier when I mentioned it was important that pregnenolone and cortisol are both made in the adrenals? So yeah, cortisol actually comes from pregnenolone, as does progesterone. Here’s the thing: when we are under more stress, cortisol “steals” progesterone’s pathway from pregnenolone, leaving us with less progesterone.


It’s the great pregnenolone steal of 2019!! (or really any year.)

Credit: Hormones Balance

So yeah, we’re gonna go in-depth into the phenomenon of pregnenolone steal in a later post, because a lot of women face a host of physical and emotional menstrual issues due to this unfortunate occurrence.

Taking Care

In the meantime, how do you go about supporting your pregnenolone production? Well, let me start off by saying do not supplement with it unless you are instructed to do so by a very knowledgeable and savvy hormone-educated medical professional. It may cause steroid-like issues, including anxiety, anger, acne (yes, all the “A”s), mood changes, irregular heartbeat, and hair loss. Definitely don’t take it if you are on birth control or hormone-replacement therapy.

When it comes to pregnenolone support, first and foremost, get the idea out of your head that eating natural foods with cholesterol is a bad thing. Yes, your body produces 80% of the cholesterol you got going on, but you still need some from food. Good sources? Pasture-raised eggs, butter, and meat.

Eat foods high in vitamin C – broccoli, Brussels sprouts, cauliflower, red peppers – and the B vitamins – fish, eggs, liver, carrot, spinach, bananas, sweet potatoes. Vitamin C helps to increase progesterone levels and vitamin B6 does the same (if you are going supplemental form, it’s a good idea to take a B complex because they work synergistically).

Bring down your stress. As mentioned above and we’ll go into great detail later, your body will produce cortisol over your sex hormones any old day. That’s because you literally won’t be able to survive today if your body doesn’t get the cortisol going. But your brain thinks that progesterone, estrogen, and testosterone can wait (though it really can’t). So the more you are stressed, the more that pregnenolone is going to be converted to cortisol, leaving little leftover for your other fabulous keep-your-wits-about-you hormones. Some great ways to bring down your stress include meditation, acupuncture, epsom salt baths, EFT, and adaptogenic herbs.

Alright, that’s it for this lesson! Head over here next, where we get into the good, the bad, and the fabulous about PROGESTERONE. See you then!

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